A bioorthogonal (68)Ga-labelling strategy for rapid in vivo imaging.

نویسندگان

  • Helen L Evans
  • Quang-Dé Nguyen
  • Laurence S Carroll
  • Maciej Kaliszczak
  • Frazer J Twyman
  • Alan C Spivey
  • Eric O Aboagye
چکیده

Herein, we describe a fast and robust method for achieving (68)Ga-labelling of the EGFR-selective monoclonal antibody (mAb) Cetuximab using the bioorthogonal Inverse-electron-Demand Diels-Alder (IeDDA) reaction. The in vivo imaging of EGFR is demonstrated, as well as the translation of the method within a two-step pretargeting strategy.

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عنوان ژورنال:
  • Chemical communications

دوره 50 67  شماره 

صفحات  -

تاریخ انتشار 2014